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Antibody Discovery

RAPID ANTIBODY DISCOVERY SERVICES

Invenra’s Rapid Discovery Services provide an efficient, industry-leading approach to discovering monoclonal and bispecific antibodies. With cutting-edge phage display technology and our streamlined workflow, we deliver high-quality antibody leads in record time.

RAPID BISPECIFIC DISCOVERY

Features:

  • Inputs: Target ID(s), recombinant proteins, and cell lines
  • Deliverables: 10 unique B-Body® Bispecific Antibody sequences
  • Timeline – 4 months from DNA sequence submission to delivery

Process:

  1. Assessment – Invenra assesses target feasibility and compatibility for the Rapid Discovery Workflow
  2. Handoff – Clients supply purified recombinant antigens and necessary cell lines, or Invenra can source materials for an additional fee
  3. Library Screening – Invenra screens >30 proprietary human phage libraries under three selection conditions, conducting 90 screens in parallel
  4. Binding Validation – Cross-reactivity testing with up to three additional species/related proteins and affinity (KD) measurements
  5. Bispecific Expression – A 12×12 B-Body Bispecific matrix in two orientations (a total of 288 total combinations) is expressed, purified, and screened
  6. Selection and Assay – Top candidates are confirmed for target binding, self-association, polyreactivity, and functionality using a high-throughput screening assay
  7. Delivery – Data is shared with the client, and the top 10 B-Body Bispecific sequences are delivered

Advantages:

  • Speed – Fastest timelines in the industry for bispecific discovery
  • Proprietary Libraries – Gain access to Invenra’s proprietary antibody libraries, and the best possible lead molecules
  • Seamless B-Body integration – Build your bispecifics on the premiere bispecific platform with CMC-ready, in-platform discovery and proven performance
  • Flexible Commercial Licensing Options – Please contact us to discuss pricing and terms
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Outlne of the Rapid Discovery Process

Outline of the Rapid Antibody Discovery Process

 

RAPID MONOCLONAL DISCOVERY

Features:

  • Inputs: Target ID(s), recombinant proteins, and cell lines
  • Deliverables: 15 monoclonal antibody sequences
  • Timeline – 2 months from sequence submission to delivery

Process:

  1. Assessment – Invenra assesses target feasibility and compatibility for the Rapid Discovery Workflow
  2. Handoff – Clients supply purified recombinant antigens and necessary cell lines.
  3. Library Screening – Invenra screens >30 proprietary human phage libraries under three selection conditions, conducting 90 screens in parallel
  4. Binding Validation – Cross-reactivity testing with up to three additional species/related proteins and affinity (KD) measurements
  5. Selection and Assay –Developability assessments ensure the highest-quality mAb candidates
  6. Delivery – Data is shared with the client, and the top 15 monoclonal sequences are delivered

Advantages:

  • Speed – Fastest timelines in the industry for monoclonal discovery.
  • Proprietary Libraries – Gain access to Invenra’s proprietary antibody libraries, and the best possible lead molecules
  • Flexible Commercial Licensing Options – Please contact us to discuss pricing and terms

Rapib mAb Discovery Process

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