Realizing the Potential of Multi-Specific Antibodies
The foundation of our innovation is our B-Body™ multi-specific antibody platform – a versatile antibody construct designed for improved expression, purification, and stability, and to enable a broad array of mechanisms of action from human IgG-like scaffolds. Building off of this foundation, we have developed a fully integrated candidate discovery platform that has already delivered multiple pre-clinical candidates for us and our partners.
The SNIPER™ Advantage
One key to our platform is our SNIPER approach, focusing on bi- and multi-specific antibodies targeting distinct, high-value targets. To date, we have successfully developed candidates with proven weak monovalent affinity to individual targets, but strong avidity to specific combinations of targets. This not only maximizes specificity and potential efficacy, but also minimizes possible side effects and toxicity through significant reduction of off-target/systemic binding.
In addition to their highly specific target-binding capabilities, our multi-specific SNIPERs are able to deliver a wide range of cargo, enabling a corresponding wide range of potential functionality, including site-specific delivery of radionuclides, antibodies to initiate ADCC (antibody-dependent cellular cytotoxicity), antibody-drug conjugates (ADCs), specific elimination of pathogenic cells, and tissue-targeted re-direction of cytokines.
Our Focus in Oncology
By marshalling all of the forces of the immune system to hunt down and destroy cancer cells, we believe it is possible to cure solid tumor cancers. We also believe that our combination approach creates the opportunity to bring together all of the necessary pieces of the innate and adaptive immune system to make the tumor microenvironment (TME) vulnerable to attack without the use of personalized medicines.
We are currently advancing two SNIPER candidates through pre-clinical development that, to date, have demonstrated unparalleled combinatorial specificity and best-in-class potential across multiple oncology indications with high unmet medical needs.