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Accelerate Your Antibody Discovery Program

At Invenra, we offer flexible and powerful solutions to meet your antibody discovery needs—whether you require rapid bispecific and monoclonal antibody discovery or a flexible scale, high-yield monoclonal or bispecific antibody expression for lead molecule development.

Rapid Discovery

Our new Rapid Bispecific Discovery Services or Rapid Monoclonal Discovery Services, powered by the B-Body® Bispecific Platform, deliver lead panels in just 2–4 months through functional screening of 250+ bispecific combinations from 90 parallel discovery screens.

Antibody Expression

Once lead panels are identified, you can seamlessly add antibody expression in multiple scale formats, enabling both high-throughput functional testing and large-scale preclinical studies with all the benefits of the high-yielding B-Body Platform.

Fast-track your therapeutic antibody development today—contact us to learn more!

Services Overview

Service

Key Features

Deliverables

Delivery Timeline

Rapid Bispecific Discovery
  • Functional screening of 250+ bispecific combinations
  • 90 parallel discovery screens
  • B-Body® Platform-driven efficiency  
  • 10 unique B-Body Bispecific sequences

2–4 months

Rapid Monoclonal Discovery
  • Rapid discovery workflow
  • Functional screening and prioritization
  • 15 monoclonal antibody sequences

2 months

B-Body Expression
  • Multiple expression scale options
  • High-throughput compatible
  • Supports large-scale preclinical work
  • Purified mAb or B-Body Bispecifics in 50 mL, 200 mL, or 500 mL formats

8 weeks

Available Antibody Services

Bispecific Discovery

Outlne of the Rapid Discovery Process

Outline of the Rapid Antibody Discovery Process Invenra’s Rapid Discovery Services provide an efficient, industry-leading approach to discovering monoclonal and bispecific antibodies. With cutting-edge phage display technology and our streamlined workflow, we deliver high-quality antibody leads in record time.

Rapid Bispecific Discovery

Features:

  • Inputs: Target ID(s), recombinant proteins, and cell lines
  • Deliverables: 10 unique B-Body® Bispecific Antibody sequences
  • Timeline – 4 months from DNA sequence submission to delivery

Process:

  1. Assessment – Invenra assesses target feasibility and compatibility for the Rapid Discovery Workflow
  2. Handoff – Clients supply purified recombinant antigens and necessary cell lines, or Invenra can source materials for an additional fee
  3. Library Screening – Invenra screens >30 proprietary human phage libraries under three selection conditions, conducting 90 screens in parallel
  4. Binding Validation – Cross-reactivity testing with up to three additional species/related proteins and affinity (KD) measurements
  5. Bispecific Expression – A 12×12 B-Body Bispecific matrix in two orientations (a total of 288 total combinations) is expressed, purified, and screened
  6. Selection and Assay – Top candidates are confirmed for target binding, self-association, polyreactivity, and functionality using a high-throughput screening assay
  7. Delivery – Data is shared with the client, and the top 10 B-Body Bispecific sequences are delivered

Advantages:

  • Speed – Fastest timelines in the industry for bispecific discovery
  • Proprietary Libraries – Gain access to Invenra’s proprietary antibody libraries, and the best possible lead molecules
  • Seamless B-Body integration – Build your bispecifics on the premiere bispecific platform with CMC-ready, in-platform discovery and proven performance
  • Flexible Commercial Licensing Options – Please contact us to discuss pricing and terms

Monoclonal Discovery

Monoclonal Ab Discovery Overview

Rapid Monoclonal Discovery

Features:

  • Inputs: Target ID(s), recombinant proteins, and cell lines
  • Deliverables: 15 monoclonal antibody sequences
  • Timeline – 2 months from sequence submission to delivery

Process:

  1. Assessment – Invenra assesses target feasibility and compatibility for the Rapid Discovery Workflow
  2. Handoff – Clients supply purified recombinant antigens and necessary cell lines.
  3. Library Screening – Invenra screens >30 proprietary human phage libraries under three selection conditions, conducting 90 screens in parallel
  4. Binding Validation – Cross-reactivity testing with up to three additional species/related proteins and affinity (KD) measurements
  5. Selection and Assay –Developability assessments ensure the highest-quality mAb candidates
  6. Delivery – Data is shared with the client, and the top 15 monoclonal sequences are delivered

Advantages:

  • Speed – Fastest timelines in the industry for monoclonal discovery.
  • Proprietary Libraries – Gain access to Invenra’s proprietary antibody libraries, and the best possible lead molecules
  • Flexible Commercial Licensing Options – Please contact us to discuss pricing and terms

Antibody Expression

SDS Page analysis of expressed antibody

Expressed Antibody Results High-yield, high-purity B-Body Bispecific Antibody purified by one-step Protein A purification following transient expression CHO cells, demonstrating stability and purity in reducing and nonreducing PAGE.

B-Body Expression

Accelerate your antibody discovery and development with Invenra’s rapid antibody expression services. Whether you need small-scale screening in high-throughput formats or larger quantities for validation, we deliver high-quality, purified antibodies in just 8 weeks—with no material caps and flexible licensing options.

Features:

  • Inputs: Your antibody sequences
  • Deliverables:
    • Two-step purified mAb or B-Body Bispecific Abs
    • QC analysis of expressed antibodies
  • Timeline – 8 weeks from DNA construction to antibody shipment
  • Flexible Scale – Choose 50mL, 200mL or 500mL expression

Process:

  1. Design & Quote – Collaborate with our team to select from our validated mAb or B-Body formats, desired sample quantiy and expression scale
  2. Express & Purify – We prepare DNA constructs, express, and 2-step purify your antibodies for high purity
  3. Analyze & Deliver – Receive QC analyzed Abs — with no retention limits (you receive the entire yield of Ab)

Advantages:

  • Seamless B-Body Integration– Test bispecifics alongside traditional mAbs
  • Flexible Formats – Choose from mAb or 1×1 formats
  • Three Production Scale Options – Select between 50mL, 200mL or 500mL expression scales and all produced antibody is yours
  • Full Service Production – Invenra manages all aspects of antibody production from DNA ordering, expression, and two-step purification and characterization
  • Rapid Antibody Availability – Fully purified material is delivered in 8 weeks from DNA construction
  • Flexible Commercial Licensing Options – Please contact us to discuss pricing and terms
HPLC Analysis of Expressed Antibodies

93% Purity After One Step Protein A Purification
HPLC analysis illustrates the high yield and-purity possible with B-Body® Bispecific antibody expression and one-step purification. Bispecific Ab was transiently expressed in CHO cells and purified by Protein A purification. HPLC analysis provides readouts of yield and purity as well as valuable, predictive insights for analytical development, downstream processing, and formulation optimization.

Get Started with Invenra Antibody Discovery & Expression

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